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'Grey's Anatomy' Season 14 Spoilers: Izzie, Cristina, George Return for 300th Episode

"Grey's Anatomy" celebrates its 300th episode this Thursday, Nov. 9, in a big way. Former characters Izzie, Cristina, and George will return to the show but not in a way that fans expect.

Katherine Heigl, Sandra Oh and T.R. Knight played the show's original characters in the earlier seasons. The actors, however, won't be appearing in the upcoming episode but the spirit of their characters will be felt on the show.

"Our three guest actors on the show actually really look like them and remind the rest of the doctors of those characters," Sarah Drew, who plays Dr. April Kepner said. "That causes the original group to really remember those people well and want to fight for these ones to live."

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"Grey's Anatomy" originally began as a story about the interns Izzie, Cristina, and George along with Meredith Grey (Ellen Pompeo) and Alex Karev (Justin Chambers). The show has since expanded its cast and storylines since the actors playing them moved on.

Knight first broke away from the show after season 5. He cited his character's screen time grew fewer following an altercation with a fellow cast member. Heigl immediately followed Knight's exit when she chose to build a movie career and did films like "Knocked Up" (2007) and "27 Dresses" (2008).

Oh, on the other hand, left the show after ten seasons. She planned her exit a year before and worked out the details with show creator Shonda Rhimes, including her potential return for a guest spot but that has never happened,

"There are certain things that Shonda and I talk about once and then we leave it because we want things to happen without pressure," Oh told The Hollywood Reporter.

Meanwhile, the current stars of "Grey's Anatomy" are elated that the series is on its 300th episode. They believe no show will reach this stage anymore with the advent of streaming platforms and series getting shorter and shorter episode counts.

"Grey's Anatomy" season 14's 300th episode will air Thursday, Nov. 9, at 9:00 p.m. EST on ABC.

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